ADV - Care Pharmacy
195 Riviera Dr. Unit #2,Markham,Ontario
Tel: (905)948-1991

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Brand Name
Common Name
How does this medication work? What will it do for me?

Moxifloxacin is an antibiotic that belongs to the group of medications known as quinolones. It is used to treat infections caused by certain bacteria.

Moxifloxacin tablets are most commonly used to treat infections of the sinuses and lungs. Moxifloxacin given intravenously (injected into a vein) is most commonly used to treat infections of the lungs and complicated infections of the skin and abdomen.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The recommended adult dose of moxifloxacin is 400 mg once daily. The medication may be taken for 5 to 21 days depending on the particular infection being treated.

Moxifloxacin tablets should be swallowed whole with plenty of fluids. They may be taken with or without food. Moxifloxacin tablets should be taken at least 4 hours before or 8 hours after multivitamins that contain iron or zinc, antacids that contain magnesium or aluminum, or sucralfate. Ask your pharmacist if you are not sure if your multivitamins or antacids contain these ingredients.

Moxifloxacin intravenous solution is given into a vein over 60 minutes.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with the next dose 24 hours later. Do not take more than 1 dose within any 24 hour period. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store the tablets at room temperature and do not allow them to freeze. The intravenous solution is stored at room temperature and protected from light.

Keep this medication out of the reach of children.

What form(s) does this medication come in?

Each oblong, dull red film-coated tablet, engraved "BAYER" on one side and "M400" on the other, contains moxifloxacin HCl equivalent to moxifloxacin 400 mg. Nonmedicinal ingredients: cellulose microcrystalline, croscarmellose sodium, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, polyethylene glycol 4000, red ferric oxide, and titanium dioxide.

Intravenous Injection
Each premixed, ready-to-use 250 mL minibag contains moxifloxacin HCl equivalent to 400 mg of moxifloxacin in 0.8% saline, with pH ranging from 4.1 to 4.6. The appearance of the intravenous solution is yellow and is not affected by, or indicative of, product stability. Nonmedicinal ingredients: sodium chloride, USP, and water for injection, USP. It may also contain hydrochloric acid and/or sodium hydroxide for pH adjustment. No further dilution of this product is necessary.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to moxifloxacin or any ingredients of the medication
  • are allergic to other quinolone antibiotics (e.g., ciprofloxacin, norfloxacin)
What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • dizziness
  • headache
  • indigestion
  • mild diarrhea
  • nausea
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • anxiety
  • depression
  • diarrhea (watery and severe; may also be bloody)
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • muscle or joint pain
  • numbness, tingling, or weakness
  • pain, inflammation, or swelling in shoulders, hands, or legs
  • severe abdominal or stomach cramps
  • swelling, redness, or other irritation at the place of injection (for intravenous only)
  • symptoms of liver problems, e.g.:
    • abdominal pain
    • dark urine
    • jaundice (yellowing of the skin or eyes)
    • nausea
    • pale stools
  • tremors

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • confusion or changes in thought patterns
  • fainting
  • irregular or fast heart rate
  • seizures
  • signs of an allergic reaction, e.g.:
    • hives
    • difficulty breathing
    • swelling of the face, tongue, or throat
  • skin rash, especially if skin is blistering, loosening, or peeling

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.


March 14, 2012

Health Canada has issued new information concerning the use of Avelox: (moxifloxacin). To read the full report, visit Health Canada's website at

A previous advisory on Avelox: was issued on November 7, 2011.

To read the full Health Canada Advisory, visit Health Canada's web site at

Allergic reactions: In rare cases, some people may develop a severe allergic reaction to this medication. Signs of a severe reaction include a severe rash, swollen face, or difficulty breathing. If these occur, get immediate medical attention.

Antibiotic-related diarrhea: As with other antibiotics, moxifloxacin can cause a severe form of diarrhea associated with the condition pseudomembranous colitis. If you develop severe diarrhea while taking this medication, contact your doctor.

Behaviour and movement changes: Rarely, this medication can cause behaviour and movement changes such as agitation, anxiety, confusion, depression, tremors, hallucinations, and other mood changes. If you experience any of the above, stop taking this medication and contact your doctor immediately.

Driving and operating heavy machinery: Moxifloxacin may impair your ability to drive or operate machinery, especially when combined with alcohol. Do not drive or operate machinery until you know how this medication will affect you.

Liver problems: This medication may cause liver problems that in rare cases can be fatal. If you experience symptoms of liver problems (yellowing of the skin and eyes, abdominal pain, dark urine, pale stools, loss of appetite, itchy skin) while taking this medication, contact your doctor immediately. People with a severe reduction in liver function should not use this medication.

Neuromuscular disorders: People with myasthenia gravis (an autoimmune disorder that causes muscle weakness) should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Palpitations and fainting spells: See a doctor as soon as possible if you experience palpitations (irregular or rapid heartbeat) or fainting spells while taking moxifloxacin.

Peripheral neuropathy: Although rare, moxifloxacin may affect the nerves of the skin and limbs. If you start to feel pain, burning, tingling, numbness, or weakness, stop taking this medication and contact your doctor immediately.

QT prolongation: This medication can lengthen heartbeat as shown on an electrocardiogram test, also known as QT prolongation. Very rare cases of abnormal heartbeat have been reported in people while on moxifloxacin, but these reports generally involved people who had conditions that predisposed them to abnormal heartbeat, or who have been taking other medications that can increase the risk of developing an abnormal heartbeat. If you develop heart palpitations (fast or irregular heartbeat) or experience fainting spells, stop taking this medication and contact your doctor immediately.

Seizures: Seizures may rarely occur with this medication. If you have a medical condition that would increase the risk of seizures, your doctor will monitor you closely. If you have a seizure while taking this medication, stop taking it and get immediate medical attention.

Sun sensitivity: People who take moxifloxacin may be more likely to experience sunburn. While taking moxifloxacin, avoid excessive sunlight or artificial ultraviolet light exposure (e.g., sun beds, sunlamps). Stop taking the medication and contact your doctor if sun sensitivity occurs.

Tendonitis: Moxifloxacin may increase the chance of tendon injury. Injury occurs more commonly for seniors who are also taking corticosteroid medications. If there is any new pain in the tendons, stop taking moxifloxacin, avoid physical exercise, and consult your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, stop taking it immediately and contact your doctor.

Breast-feeding: It is not known if moxifloxacin passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children under 18 years of age.

What other drugs could interact with this medication?

There may be an interaction between moxifloxacin and any of the following:

  • antacids containing aluminum hydroxide and magnesium hydroxide (take moxifloxacin 4 hours before or 8 hours after these medications)
  • BCG vaccine
  • buffered antiretroviral medications (e.g., didanosine)
  • certain antidiabetes medications (e.g., insulin, glyburide, gliclazide)
  • certain antipsychotics (e.g., haloperidol)
  • certain medications for abnormal heart rhythms (e.g., quinidine, procainamide, sotalol, amiodarone)
  • certain tricyclic antidepressants (e.g., amitriptyline)
  • erythromycin
  • iron supplements or multivitamins that contain iron or zinc (take moxifloxacin 4 hours before or 8 hours after these medications)
  • nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, naproxen)
  • pimozide
  • quinapril
  • sucralfate (take moxifloxacin 4 hours before or 8 hours after these medications)
  • typhoid vaccine
  • warfarin
  • ziprasidone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

The contents of this site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.
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