ADV - Care Pharmacy
195 Riviera Dr. Unit #2,Markham,Ontario
Tel: (905)948-1991

Return to Home Page      Print Page      Check Price
Brand Name
Celebrex
Common Name
celecoxib
How does this medication work? What will it do for me?

Celecoxib belongs to the group of medications called selective COX-2 inhibitor nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing a substance in the body that leads to inflammation and pain. By this action, it relieves pain and reduces swelling and inflammation. It is used to treat the symptoms of osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis in adults.

It is also used to treat moderate to severe pain for a short-term period (less than 7 days), such as pain due to surgery, sprains, or tooth extractions.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The amount of celecoxib and how long it is taken varies according to the condition being treated. It should be used at the lowest dose possible to achieve pain relief.

Osteoarthritis: The usual recommended daily dose is 200 mg taken as a single dose or as 100 mg twice daily.

Ankylosing spondylitis: The usual recommended daily dose is 200 mg taken as a single dose or as 100 mg twice daily.

Rheumatoid arthritis: The usual recommended starting dose is 100 mg twice daily. This may be increased to 200 mg twice daily as directed by your doctor.

Moderate to severe pain: The usual recommended dose is 400 mg as a single dose on the first day, followed by 200 mg once daily. Treatment should not exceed 7 days. The maximum recommended dose is 400 mg a day.

Celecoxib may be taken with or without food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

What form(s) does this medication come in?

100 mg
Each white to off white hard gelatin capsule, with blue ink band on body marked in white with "100" and with blue ink band on cap marked in white with "7767", contains 100 mg of celecoxib. Nonmedicinal ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone, and sodium lauryl sulfate; shell: edible ink (indigotine [E132]), gelatin, and titanium dioxide (E171).

200 mg
Each white to off-white hard gelatin capsule, with gold ink band on body marked in white with "200" and with gold ink band on cap marked in white with "7767", contains 200 mg of celecoxib. Nonmedicinal ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone, and sodium lauryl sulfate; shell: edible ink (ferric oxide [E172]), gelatin, and titanium dioxide (E171).

Who should NOT take this medication?

Celecoxib should not be taken by anyone who:

  • is allergic to celecoxib or to any of the ingredients of the medication
  • is allergic to sulfonamides (sulfa medications; e.g., sulfamethoxazole)
  • is breast-feeding or planning to breast-feed
  • is in the third trimester of pregnancy (28 weeks or more)
  • is planning to have or recently had open heart surgery
  • has an active stomach or intestinal ulcer or active gastrointestinal (stomach and intestines) bleeding
  • has bleeding in the brain
  • has experienced asthma, hives, or allergic-type reactions after taking acetylsalicylic acid (ASA) or other NSAIDs (e.g., naproxen, ibuprofen, diclofenac, meloxicam)
  • has high blood potassium levels
  • has inflammatory bowel disease
  • has severe, uncontrolled heart failure
  • has severely impaired kidney function or kidney function that is getting worse
  • has severely impaired liver function or active liver disease
What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • diarrhea
  • dizziness
  • drowsiness
  • gas
  • headache
  • heartburn
  • increased sensitivity to sunlight
  • nausea
  • ringing in the ears
  • runny nose
  • sinus pain
  • skin rash
  • sore throat

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • fast heartbeat
  • fatigue
  • hearing changes
  • increased blood pressure
  • signs of bleeding (e.g., unusual bruising or bleeding, bloody nose, blood in urine, coughing blood, cuts that won't stop bleeding)
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • swelling of the legs or feet
  • symptoms of liver damage (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite, nausea and vomiting, or itching)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • bladder symptoms such as bladder pain, difficulty or pain passing urine, urinary frequency, or blood in the urine
  • blurred vision or other vision changes
  • signs of a heart attack (e.g., pain or discomfort in the chest, neck, jaw, back, or stomach; shortness of breath; sweating; nausea; or lightheadedness)
  • symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; or swelling of the lips, throat, or tongue)
  • symptoms of a severe skin reaction (e.g., high fever; rash, sores, or painful blisters on the skin, mouth, or eyes; or skin peeling off)
  • symptoms of a stroke (e.g., sudden confusion, trouble speaking, or understanding speech; sudden weakness or numbness, especially in one side of the body; sudden vision problems in one or both eyes; sudden loss of balance or coordination; or sudden severe headache without a known cause)
  • symptoms of bleeding in the stomach or intestines (e.g., dark and tarry stools, blood coming from rectum, vomiting blood or material that looks like coffee grounds, fast heartbeat, weakness or fainting)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergy: Some people who are allergic to sulfonamide medications such as certain antibiotics also experience allergic reactions to celecoxib. Before you take celecoxib, inform your doctor about any previous adverse reactions you have had to medications, especially sulfonamides and anti-inflammatories. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Anemia: Celecoxib may cause or worsen anemia. People with anemia should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Celecoxib may cause drowsiness or dizziness. Avoid driving, operating machinery, or engaging in other activities that require alertness and coordination if you find that celecoxib affects you in this way.

Fluid retention: Celecoxib may cause fluid retention and swelling, possibly worsening high blood pressure, congestive heart failure, or decreased heart function. People with these conditions should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you develop shortness of breath; fatigue; excessive weight gain; chest pain; or swelling of the legs, feet, or ankles while taking this medication, consult your doctor immediately.

Heart attack and stroke: The use of selective COX-2 inhibitor NSAIDs, including celecoxib, is associated with an increased risk of cardiovascular events such as heart attack and stroke, similar to the risk associated with most traditional NSAIDs (e.g., ibuprofen, diclofenac, naproxen). The risk is increased with higher total daily doses and when taking the medication over long periods of time. Due to this increased risk, people with the following conditions or risk factors should be closely monitored by their doctor if they use celecoxib:

  • congestive heart failure
  • diabetes
  • heart attack
  • heart disease
  • high blood pressure
  • high cholesterol
  • impaired kidney function
  • poor circulation
  • smoking
  • stroke

Kidney disease: Like other NSAIDs, celecoxib is not recommended for people with advanced kidney disease. People with kidney disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver disease: Celecoxib may worsen liver disease. People with liver disease or severely impaired liver function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Potassium levels: Celecoxib may increase the risk of high potassium levels in the blood - especially for seniors, people who have conditions such as diabetes or kidney failure, or those taking certain other types of medications. Your doctor may order blood tests periodically during long-term treatment to monitor the amount of potassium in your blood. People who have been diagnosed with having high potassium levels in their blood should not take this medication.

Stomach problems: Celecoxib may cause stomach problems such as ulcers or bleeding. People with stomach problems should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Call your doctor immediately if you notice signs such as stomach or abdominal pain, black tarry stools, or vomiting blood. Using acetylsalicylic acid (ASA) at the same time as celecoxib increases the risk of stomach ulcers and bleeding.

Pregnancy: The safety of using this medication during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks, and it should be avoided during the last trimester of pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are taking celecoxib, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children and adolescents under 18 years old.

What other drugs could interact with this medication?

There may be an interaction between celecoxib and any of the following:

  • ACE inhibitors (e.g., enalapril, ramipril)
  • acetylsalicylic acid (ASA) and other salicylate medications
  • alcohol
  • aluminum- and magnesium-containing antacids
  • angiotensin II antagonists (e.g., losartan, irbesartan)
  • cholestyramine
  • colestipol
  • clopidogrel
  • cyclosporine
  • digoxin
  • feverfew
  • fluconazole
  • fluouracil
  • furosemide
  • garlic
  • ginger
  • glucocorticoids (e.g., dexamethasone, hydrocortisone, prednisone)
  • green tea
  • ketoconazole
  • lithium
  • methotrexate
  • other NSAID medications (e.g., ibuprofen, ketorolac, naproxen)
  • selective serotonin reuptake inhibitors (SSRIs, e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • sulfisoxazole
  • tacrolimus
  • thiazide diuretics (e.g., hydrochlorothiazide)
  • thioridazine
  • ticlopidine
  • tolbutamine
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.





The contents of this site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.
© 1996 - 2014 MediResource Inc. - Targeted Health Solutions
Return to Home Page