ADV - Care Pharmacy
195 Riviera Dr. Unit #2,Markham,Ontario
Tel: (905)948-1991

Return to Home Page      Print Page      Check Price
Brand Name
Apo-Glimepiride
Common Name
glimepiride
How does this medication work? What will it do for me?

Glimepiride belongs to a group of medications known as oral hypoglycemics. It is used to control blood sugar for people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood sugar well enough on their own. Glimepiride increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently.

Glimepiride may be used when diet and exercise do not provide adequate control of blood sugar. It may be used in combination with metformin or insulin when diet and exercise and the use of these medications on their own do not provide adequate control of blood sugar.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The usual starting dose is 1 mg once daily to be taken with breakfast or the first main meal. After reaching a dose of 2 mg, further increases should be done in increments of no more than 1 mg at one-week to 2-week intervals, based on the response. The usual maintenance adult dose ranges from 1 mg to 4 mg once daily to be taken with breakfast or the first main meal of the day. The maximum daily dose is 8 mg.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking this medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

What form(s) does this medication come in?

1 mg
Each pink, flat-faced, bevelled-edge, indented capsule-shaped tablet, engraved "GLM" deep bisect "1" on one side, "APO" deep bisect "APO" on the other side, contains glimepiride 1 mg. Nonmedicinal ingredients: anhydrous lactose, corn starch, magnesium stearate, and red ferric oxide.

2 mg
Each green, flat-faced, bevelled-edge, indented capsule-shaped tablet, engraved "GLM" deep bisect "2" on one side, "APO" deep bisect "APO" on the other side, contains glimepiride 2 mg. Nonmedicinal ingredients: anhydrous lactose, corn starch, magnesium stearate, indigotine aluminum lake, and yellow ferric oxide.

4 mg
Each blue, flat-faced, bevelled-edge, indented capsule-shaped tablet, engraved "GLM" deep bisect "4" on one side, "APO" deep bisect "APO" on the other side, contains glimepiride 4 mg. Nonmedicinal ingredients: anhydrous lactose, corn starch, magnesium stearate, and indigotine aluminum lake.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to glimepiride or any ingredients of the medication
  • are pregnant or breast-feeding
  • have type 1 diabetes (i.e., insulin-dependent diabetes)
  • have diabetic ketoacidosis, with or without coma
What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • dizziness
  • headache
  • nausea
  • weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision
  • fever
  • general feeling of illness
  • increased skin sensitivity or skin rashes following sun exposure
  • signs of high blood sugar (hyperglycemia):
    • dry mouth
    • dry skin
    • flushing
    • frequent urination
    • loss of appetite
    • thirst
    • tiredness
    • trouble breathing
  • signs of low blood sugar (hypoglycemia):
    • blurred vision
    • dizziness
    • fatigue
    • headache
    • numbness or tingling of the mouth
    • pale colour
    • rapid heartbeat
    • shakiness
    • sudden hunger
    • sweating or confusion
    • weakness
  • signs of liver damage
    • abdominal pain
    • dark urine
    • fatigue
    • fever
    • loss of appetite
    • yellow skin or eyes
  • skin redness, itching, or rash
  • sore throat
  • swelling of the hands or feet
  • unusual tiredness or weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • signs of an allergic reaction:
    • difficulty breathing
    • hives
    • swelling of the face or throat
  • signs of bleeding:
    • bleeding gums
    • blood in the urine
    • dark tarry stools
    • easy bruising
    • nosebleeds
    • vomiting blood
  • signs of low blood sugar: (such as convulsions or seizures, loss of consciousness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: This medication can cause drowsiness or reduced alertness. Do not drive or engage in other activities requiring alertness if the medication affects you in this way.

Hypoglycemia (low blood sugar): Hypoglycemia is a condition in which blood sugar levels are abnormally low. Symptoms of hypoglycemia include:

  • dizziness
  • drowsiness
  • headache
  • lack of energy
  • nervousness
  • numbness or tingling of the mouth
  • shakiness
  • sweating
  • weakness

People with more severe hypoglycemia can experience blurred vision, confusion, and an inability to concentrate. If left untreated, severe hypoglycemia can lead to convulsions (seizures) and unconsciousness within minutes. People who are more likely to become hypoglycemic include seniors, people with reduced liver or kidney function, people who are malnourished, or people taking beta-blockers or other medications that lower blood sugar. Low blood sugar is more likely to occur when food intake is inadequate, or after strenuous or prolonged physical exercise. Blood sugar should be monitored regularly and an emergency source of sugar (e.g., a sugar packet, orange juice, or hard candy) and glucagon kit should be made available in case the need arises to increase blood sugar levels.

Loss of blood sugar control: People on glimepiride may experience loss of blood sugar control during illness or stressful situations such as fever, infection, trauma, or surgery. Under these conditions, your doctor may consider stopping the medication and prescribing insulin until your blood sugar is controlled and within target levels. For some people, their doctor may prescribe insulin or metformin in combination with glimepiride to control blood sugar.

Proper diet: Glimepiride is a treatment to be used in combination with a proper diet. Glimepiride is not as a substitute for a proper diet.

Worsening of condition: Over a period of time, glimepiride may become less effective because of the worsening of diabetes. Talk to your doctor if glimepiride no longer controls your blood glucose to target levels. Your doctor may ask you to stop this medication, or continue this medication and take an additional antidiabetic medication to help control your blood sugar.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if glimepiride passes into breast milk. Breast-feeding mothers should not take glimepiride.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with this medication?

There may be an interaction between glimepiride and any of the following:

  • acetylsalicylic acid (ASA)
  • alcohol
  • anabolic steroids
  • barbiturates (e.g., phenobarbital, secobarbital)
  • beta-blockers (e.g., atenolol, metoprolol)
  • chloramphenicol
  • clarithromycin
  • clonidine
  • corticosteroids (e.g., prednisone)
  • cyclophosphamide
  • diazoxide
  • disopyramide
  • diuretics (e.g., hydrochlorothiazide, acetazolamide)
  • epinephrine
  • estrogens (e.g., conjugated estrogens)
  • fibrates (e.g., fenofibrate)
  • fluoroquinolones (e.g., ciprofloxacin, ofloxacin)
  • fluoxetine
  • glucagon
  • guanethidine
  • H2-receptor antagonists (e.g., raniditine)
  • ifosfamide
  • isoniazid
  • laxatives (after prolonged use)
  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • nonsteroidal anti-inflammatory drugs (e.g., naproxen)
  • phenytoin
  • phenothiazines (e.g., chlorpromazine)
  • phenylbutazone
  • probenecid
  • progestogens (e.g., medroxyprogesterone)
  • propranolol
  • reserpine
  • rifampin
  • salicylates (e.g., ASA, salsalate)
  • sulfonamides (e.g., sulfamethoxazole)
  • sympatReturn to Home Pagetics (cough, cold or allergy medication)
  • testosterone
  • tetracyclines (e.g., tetracycline, minocycline)
  • thyroid hormones (e.g., levothyroxine)
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.





The contents of this site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.
© 1996 - 2014 MediResource Inc. - Targeted Health Solutions
Return to Home Page